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Type of Event: Evaluation Examination
Speaker: M.Sc. José Alfredo Vázquez Sandoval
Day: 2022-09-27, at 12:00:00 hrs.
Place: TEAMS Videoconference
Title: FAM129B is a cooperative protein that regulates adipogenesis
Abstract:

FAM129B has been poorly studied protein and is related to cell migration and apoptosis suppression. However its role in cell differentiation has not been explored yet. Fam129b gene is expressed in 3T3-F442A cell line downstream of the early genes C/EBPβ, Klf4, Klf5, and Srebf1a; during commitment adipose process but upstream of Pparg2 along with a battery of genes that control adipose phenotype expression. The gene expression of FAM129B is regulated through GSK3β, a crucial kinase in the signaling pathway of adipogenesis, which also participates in FAM129B phosphorylation. Moreover FAM129B regulates clonal amplification, since its expression is essential to adipose cluster formation

Type of Event: Evaluation Examination
Speaker: M.Sc. Nínive Tanairy Rodríguez Ochoa
Day: 2022-11-11, at 12:00:00 hrs.
Place: TEAMS Videoconference
Title: Effect of lactoferrin on processes of migration, invasion and secretion of extracellular vesicles in MDA-MB-231 cells and in a murine model
Abstract:

Breast cancer is the leading cause of death for women in the world, accounting for 25% of all cancer cases, which is why it is considered a major public health problem. Currently, most of the available anticancer treatments generate a large number of side effects in patients, so it is important to explore the use of non-toxic natural products. In this context the idea of studying the effect of lactoferrin (Lf) arises, due to its high nutritional value and the presence of various studies that highlight its anticancer effect on different types of cancer. In the present work, the effect of lactoferrin on cellular processes involved in tumor progression was evaluated. Bovine Lf will decrease the migration and invasion generated by SFB and AL in MDA-MB-231 mammary cancer epithelial cells and, as well as the negative regulation of the expression of the mesenchymal marker vimentin and not of the epithelial marker E-cadherin, it will also increase having an effect on the activation of FAK-Tyr397 and the dynamics of focal contact formation, and secretion of VEs

Type of Event: Evaluation Examination
Speaker: M.Sc. Lidia Caridad Díaz Fernández
Day: 2022-11-23, at 11:30:00 hrs.
Place: TEAMS Videoconference
Title: SNX10 as a tumor suppressor in HCC
Abstract:

Hepatocellular carcinoma is the third type of cancer with the highest number of deaths worldwide. SNX10 is a protein belonging to the “Sorting Nexin” family whose members have the PX phosphoinositide binding domain. SNX10 participates in endosomal regulation and could potentially act as a tumor suppressor in cancer, since it is underexpressed in a model of chemical hepatocarcinogenesis in rats and in colon cancer. In colorectal carcinoma it is a negative regulator of chaperone-mediated autophagy. Chaperone-mediated autophagy is a type of autophagy in which substrates are degraded via the lysosomal pathway. In recent years it has been studied for having pro-oncogenic characteristics in the development of cancer. The main idea of ​​our work was to evaluate the role of SNX10 in the development of hepatocellular carcinoma. We obtained that the expression level of SNX10 is high in HCC cells with epithelial characteristics and low in HCC cells with mesenchymal characteristics, as well as in tumors from an animal model of HCC and in tumors from patients with HCC. miR-30d and SNX10 have a negative connection in HCC cells and this miR-30d is one of the negative regulators of SNX10 in HCC. This protein negatively regulates LAMP2A protein and positively regulates p21 and IκBα proteins in HCC cells. It is also a negative regulator of AFP, BCL-2, and DKK1 transcription. SNX10 acts as a tumor suppressor by negatively regulating the appearance, migration, invasion, and tumorigenesis of HCC

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